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Updated: Jun 8, 2026

DNAzyme-dependent Analysis of rRNA 2’-O-Methylation
09:12

DNAzyme-dependent Analysis of rRNA 2’-O-Methylation

Published on: September 16, 2019

一个外环甲基作为LNA中的2'-氧原子的生物基

Punit P Seth1, Charles R Allerson, Andres Berdeja

  • 1Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc., 1891 Rutherford Road, Carlsbad, California 92008, USA. pseth@isisph.com

Journal of the American Chemical Society
|October 5, 2010
PubMed
概括

研究人员开发了甲-碳循环锁定核酸 (cLNA) 类似物,模仿锁定核酸 (LNA) 的结合亲和力和活性. 这些新型cLNA的性能与LNA相似,但在动物研究中毒性降低.

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