增强的外部反推力改善了慢性心痛患者的外周动脉流介导扩张:一项随机化模拟控制研究
Randy W Braith1, C Richard Conti, Wilmer W Nichols
1Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. rbraith@hhp.ufl.edu
Circulation
|October 6, 2010
概括
增强的外部反推力 (EECP) 改善了外周动脉功能,并减少了冠状动脉疾病患者的炎症. 这项研究提供了EECP的证据.
科学领域:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 非侵入性心脏病学 非侵入性心脏病学
背景情况:
- 增强的外部对冲动 (EECP) 抗胰岛素效应的机制尚不清楚.
- 这项研究调查了EECP对外心脏对外周围动脉流介导扩张的影响.
- 这是对这些效应的第一个随机模拟控制的随机调查.
研究的目的:
- 为了研究EECP对外心脏对外围动脉流介导扩张的影响.
- 探索EECP对内皮功能和血管活性剂的影响.
- 为EECP在冠状动脉疾病中的益处提供机械证据.
主要方法:
- 随机化模拟对照试验,对42名症状冠状动脉疾病患者进行了随机化模拟对照试验.
- 35个1小时的EECP或假EECP课程.
- 超声波评估手臂和大腿动脉流介导扩张.
- 对氧化,炎症和氧化应激的血标记物的测量.
主要成果:
- 与假药相比,EECP显著增加了手臂和大腿动脉流介导扩张.
- EECP改善了氧化生产标记物,并减少了内皮-1和不对称的二甲基氨酸.
- EECP降低了促炎细胞因子,粘附分子和氧化应激标志物.
- 在治疗组中,EECP显著降低了心痛的分类.
结论:
- 在患有症状冠状动脉疾病的患者中,EECP增强了外周动脉流介导扩张.
- EECP积极调节内皮衍生的血管活性剂,并减少炎症.
- 这些发现为EECP的治疗益处提供了新的机制证据.
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