对RORgammat+先天性淋巴细胞的血统关系分析
Shinichiro Sawa1, Marie Cherrier, Matthias Lochner
1Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France.
概括
预炎性RORγt(+) 原生淋巴细胞 (ILCs) 启动淋巴组织发育和肠道平衡. 这些细胞独立于微生物群发育,这表明它们在预防微生物殖民的过程中发挥了作用.
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 微生物组研究 微生物组研究
背景情况:
- 淋巴组织诱导细胞 (LTi) 通过树皮细胞激活启动淋巴组织发育.
- LTi细胞表达核激素受体RORγt,该受体也调节T细胞中介质-17的表达.
研究的目的:
- 描述RORγt的更广泛的家族 ((+) 原生淋巴细胞 (ILCs).
- 研究RORγt (((+) ILCs与肠道平衡和微生物相互作用有关的发育途径和功能.
主要方法:
- 在胎儿和成年小鼠中分析RORγt (((+) 细胞群.
- 调查ILC与胎儿肝脏前体的差异化.
- 评估在微生物群存在或不存在的情况下ILC的发展.
主要成果:
- LTis是源自胎儿肝脏前体的更大的促炎性RORγt(+) ILCs家族的一部分.
- RORγt ((+) ILCs的发育命运受老鼠年龄的影响,有利于肠道平衡和出生后的防御.
- RORγt(+) ILCs与微生物群独立发展,与RORγt(+) T细胞不同.
结论:
- RORγt(+) ILCs代表了一种独特的先天性免疫细胞系,参与启动淋巴细胞组织的形成.
- 这些细胞在建立肠道平衡和防御机制方面发挥着至关重要的作用.
- RORγt (((+) ILCs在没有微生物群的情况下发育的能力表明它们是为了防止微生物共生体的殖民而开创的.
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