在唾液器官生成过程中,寄生交感内置维持了上皮原生细胞
S M Knox1, I M A Lombaert, X Reed
1Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA.
概括
副交感神经通过使用乙胆信号来维持上皮原生细胞的器官发育. 这一途径涉及M1和表皮生长因子受体,对于器官生成至关重要,并可能有助于修复.
科学领域:
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
- 神经科学是一个神经科学.
背景情况:
- 亲生细胞的维护对于器官的发育和再生至关重要.
- 在器官生成过程中表皮原生细胞调节的机制尚未完全理解.
研究的目的:
- 为了研究寄生交感内置在维持在有机发生过程中的上皮原生细胞中的作用.
- 为了阐明参与这个过程的信号通路.
主要方法:
- 鼠标扩展器官培养被用于研究上皮原生细胞.
- 移除了副交感性,并评估了使用和不使用乙胆类比治疗的效果.
- 分析了表达和信号通路,包括肌肉M1和表皮生长因子受体.
主要成果:
- 移除副交感性质细胞减少了 keratin 5 阳性上皮原生细胞的数量,并改变了其形态发生.
- 乙胆类比治疗挽救了这些效应,表明具有保护作用.
- 由M1和表皮生长因子受体介导的乙胆信号传递促进了表皮形态发生和祖细胞增殖.
结论:
- 副交感内置对于在器官生成过程中保持表皮原生细胞群体在未分化状态至关重要.
- 这种机制对于正确的器官发育至关重要.
- 针对这种乙胆介导途径,有可能用于器官修复和再生策略.
相关概念视频
Cranial Part of Parasympathetic Division
The cranial part of the parasympathetic division plays a crucial role in regulating the visceral functions of the head and specific structures in the neck, thoracic, and abdominopelvic cavities. Preganglionic fibers of the parasympathetic division exit the brain through cranial nerves III (oculomotor), VII (facial), IX (glossopharyngeal), and X (vagus), delivering parasympathetic output to the respective visceral structures.
The vagus nerve (cranial nerve X) alone accounts for approximately 75...
The vagus nerve (cranial nerve X) alone accounts for approximately 75...
Renewal of Intestinal Stem Cells
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Salivary Glands and Saliva
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
Parasympathetic Division of the ANS
The parasympathetic division of the autonomic nervous system (ANS) regulates rest and digestion functions in the body. It works in opposition to the sympathetic division, promoting relaxation, conservation of energy, and digestion. The parasympathetic division consists of preganglionic fibers originating from specific cranial nerves (III, VII, IX, X) and the sacral spinal nerves (S2-S4). These fibers synapse with postganglionic neurons in the terminal ganglia, innervating various organs and...
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Adult Stem Cells
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

