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血管内皮生长因子-B在转基因大鼠中充当冠状动脉生长因子,而不会诱导血管生成,血管泄漏或炎症
Maija Bry1, Riikka Kivelä, Tanja Holopainen
1Molecular/Cancer Biology Laboratory and Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Circulation
|October 13, 2010
概括
血管内皮生长因子-B (VEGF-B) 在老鼠中促进冠状动脉生长,与小鼠不同. 这表明缺血性心脏病的治疗潜力通过增强对心脏下内脏肌肉的动脉供应.
科学领域:
- 心血管生物学 心血管生物学
- 分子医学是分子医学.
- 血管生物学 血管生物学
背景情况:
- 血管内皮生长因子-B (VEGF-B) 在心脏,骨肌肉和棕色脂肪中表达.
- 其精确的生物功能在很大程度上仍未被定义.
研究的目的:
- 研究VEGF-B在心脏功能和血管化中的作用.
- 阐明涉及VEGF-B介导心脏影响的信号通路.
主要方法:
- 在小鼠模型中,腺相关的VEGF-B病毒输送.
- 在心肌中表达VEGF-B的转基因小鼠和老鼠的产生.
- 对VEGF受体-1和神经皮林-1信号通路的基因操纵.
主要成果:
- 在转基因小鼠和大鼠中,VEGF-B诱导心脏缩,而不会损害心功能.
- 在老鼠中,VEGF-B促进了心上和心内冠状动脉的显著生长,但不是血管生成.
- VEGF受体-1信号与VEGF-B诱导的心脏缩有关,而神经皮林-1相互作用并不重要.
结论:
- 在老鼠中,VEGF-B作为冠状动脉生长因子,与它在小鼠中的作用不同.
- 内皮信号传递介导VEGF-B诱导的心脏缩.
- 向VEGF-B可能通过改善心下内脏区域的动脉供应,为缺血性心脏病提供治疗效益.
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