用于治疗阿片类药物依赖的布普伦诺芬植入物:一个随机对照试验
Walter Ling1, Paul Casadonte, George Bigelow
1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA. lwalter@ucla.edu
JAMA
|October 14, 2010
概括
与安慰剂相比,布普伦诺芬植入物在16周内显著减少了阿片类药物依赖患者的非法阿片类药物使用. 这种新的治疗方法还改善了研究完成率,并减少了戒断症状.
科学领域:
- 药理学 药理学是指药理学的学科.
- 成 药物 药物 药物 药物
- 临床试验 临床试验
背景情况:
- 现有的阿片类药物依赖疗法面临着诸如低附和戒断症状等挑战.
- 药理干预对于管理阿片类药物使用障碍至关重要.
- 正在探索新的药物输送系统,以提高治疗疗效.
研究的目的:
- 评估布普伦诺芬植入物治疗阿片类药物依赖的有效性.
- 评估持续释放布伦诺芬植入物是否可以减少非法阿片类药物使用.
- 在一个随机对照试验中,将布普伦诺芬植入物与安慰剂进行比较.
主要方法:
- 一个为期6个月的随机化,安慰剂对照试验,涉及163名阿片类药物依赖的成年人.
- 参与者在最初的舌下布普伦诺芬-纳洛诱导后接受了布普伦诺芬植入物或安慰剂植入物.
- 分析尿液样本以检测非法阿片类药物,并评估戒断症状/渴望.
主要成果:
- 布普伦诺芬植入物导致在前16周 (P=.04) 尿样呈非合法阿片类药物阴性值显著增加.
- 使用布普伦诺芬植入物观察到更高的研究完成率 (65.7%vs30.9%,P<.001) 和减少戒断症状和渴望.
- 在这两组中,较小的植入部位反应是最常见的不良事件.
结论:
- 布普伦诺芬植入物有效地减少了阿片类药物依赖的人的非法阿片类药物使用.
- 持续释放布普伦诺芬植入物为传统治疗提供了一个有希望的替代方案.
- 该研究支持使用布普伦诺芬植入物改善阿片类药物依赖的治疗结果.
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