一个Myc网络解释了胚胎干细胞和癌细胞转录程序之间的相似之处
Jonghwan Kim1, Andrew J Woo, Jianlin Chu
1Department of Pediatric Oncology, Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.
Cell
|October 16, 2010
概括
确定了胚胎干细胞中的Myc调节网络,揭示了不同的功能模块. Myc模块与核心模块分开,在癌症中活跃,并预测结果,解释癌症和干细胞特征之间的相似性.
科学领域:
- * 分子生物学 * 分子生物学
- * 癌症研究 癌症研究
- * * 干细胞生物学
背景情况:
- *c-Myc (Myc) 是胚胎干细胞,体细胞重编程和癌症中的一个关键的转录调节器.
- *了解Myc的调节网络对于剖析细胞身份和疾病机制至关重要.
研究的目的:
- * 识别和描述ES细胞中Myc中心的调节网络.
- * 在ES细胞转录程序中定义功能模块.
- * 调查ES细胞特征与癌症之间的联系,特别是Myc.的作用.
主要方法:
- * 蛋白质-蛋白质和蛋白质-DNA相互作用研究的整合.
- * 对监管网络信息的分析.
- * ES细胞模块的定义和功能评估 (核心,多组,Myc).
主要成果:
- * 确定了ES细胞中的Myc中心调节网络,包括与NuA4复合体的相互作用.
- *定义了三个功能上可分离的ES细胞模块 (核心,多组,Myc).
- *Myc模块,独立于核心模块,在各种癌症中活跃,并预测患者的结果.
- *癌症和ES细胞特征之间的相似性主要归因于Myc网络的广泛影响.
结论:
- *ES细胞转录程序包括不同的,功能上可分离的模块.
- *Myc模块在癌症的发展和预后中发挥着重要作用,独立于核心多能性因素.
- * 菌类调节网络是ES细胞和癌细胞之间共享的转录签名的主要驱动因素.
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