超脂血症引发的中性恋会促进早期动脉样硬化
Maik Drechsler1, Remco T A Megens, Marc van Zandvoort
1Institute for Molecular Cardiovascular Research, Pauwelsstrasse 30, 52074 Aachen, Germany.
Circulation
|October 20, 2010
概括
高胆固醇会导致中性粒细胞的增加,而中性粒细胞是动脉样硬化早期发展的关键. 减少中性粒细胞减少了早期斑块的生长,突出了它们在引发这种心血管疾病中的作用.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 动脉样硬化病原体的产生
背景情况:
- 炎症和免疫细胞激活是动脉样硬化的主要原因.
- 单细胞和T淋巴细胞是已知的动脉样硬化病变形成的贡献者.
- 中性粒细胞在动脉样硬化开始和进展中的特定作用需要进一步阐明.
研究的目的:
- 为了研究高胆固醇血症对外围中性粒细胞数量的影响.
- 为了检查对动脉样硬化病变的中性粒细胞的招募.
- 确定中性粒细胞在阿波埃小鼠动脉硬化病变发展中的重要性.
主要方法:
- 在使用高脂肪饮食的阿波小鼠中诱导高胆固醇血症.
- 对外围中性粒细胞数量和骨髓动员的量化.
- 通过流细胞测量对中性粒细胞透到动脉样硬化病变的分析.
- 评估中性贫血小鼠与对照小鼠的斑块大小和组成.
主要成果:
- 高胆固醇血症导致中性粒细胞数量增加 (中性粒细胞) 由于增强的颗粒形成和骨髓动员.
- 中性恋与早期动脉样硬化病变的发展正相关.
- 中性贫的小鼠在早期阶段表现出减少的斑块大小,单细胞和巨细胞的数量发生了变化.
- 中性粒细胞在动脉中的招募在4周达到峰值,并取决于特定的化学因受体 (CCR1,CCR2,CCR5,CXCR2).
结论:
- 高胆固醇血引起的中性恋是一种复杂的过程.
- 中性粒细胞主要在动脉样硬化的早期阶段入动脉.
- 中性粒细胞在动脉样硬化开始过程中起着重要作用.
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