动脉瘤肩部应力和腹腔大动脉动脉瘤扩张之间的关联:一项纵向后续研究
Zhi-Yong Li1, Umar Sadat, Jean U-King-Im
1School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. ZYL22@cam.ac.uk
Circulation
|October 20, 2010
概括
在腹腔大动脉动脉瘤 (AAA) 中,较高的肩部应力与快速扩张有关. 这一发现可能有助于估计AAA扩张并改善患者风险分层.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 医疗成像医学成像
背景情况:
- 动脉瘤扩张率和壁应力是腹腔大动脉瘤 (AAA) 破裂风险的关键指标.
- 在AAA壁应力和膨胀动力学之间确切的关系仍然不完全理解.
研究的目的:
- 调查患者特异性AAA壁应力与动脉瘤扩张率之间的关联.
- 为了确定基线壁面应力是否可以预测未来AAA扩张.
主要方法:
- 从44名患者的连续CT扫描中重建了患者特定的3DAAA几何形状.
- 采用非线性大应变有限元分析来计算AAA壁应力分布.
- 与观察到的随着时间的推移扩张率相关联的基线肩部应力.
主要成果:
- 在缓慢扩张和快速扩张的AAA之间,基线最大直径没有显著差异.
- 快速膨胀的AAA与缓慢膨胀的AAA相比 (300kPa与225kPa) 呈现出明显更高的肩部应力.
- 在基线肩部应力和AAA扩张率 (r=0.71,P=0.0001) 之间观察到强烈的正相关性.
结论:
- 增加的肩部压力与腹腔大动脉动脉瘤的更快扩张率有关.
- 测量肩部应力可以提高AAA扩张的估计,并改善患者的风险分层.
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