怀孕期间DHA补充剂对母亲抑郁症和幼儿神经发育的影响:随机对照试验
Maria Makrides1, Robert A Gibson, Andrew J McPhee
1Child Nutrition Research Centre, Women's and Children's Health Research Institute, Women's and Children's Hospital, 72 King William Rd, North Adelaide SA 5006, Australia. maria.makrides@health.sa.gov.au
JAMA
|October 21, 2010
概括
孕妇补充多可萨赫萨酸 (DHA) 并没有减少产后抑郁症或改善儿童的神经发育. 这项随机试验发现,在怀孕期间使用富含DHA的鱼油对母亲或其后代没有显著的益处.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和儿童的健康
- 营养科学 营养科学
背景情况:
- 国际建议建议孕妇增加多可萨赫萨酸 (DHA) 的摄入量.
- 然而,关于DHA对母亲心理健康和婴儿神经发育的益处的证据仍然不确定.
研究的目的:
- 调查在怀孕晚期增加的DHA摄入量是否会减少母亲的抑郁症状.
- 评估DHA补充对儿童认知和语言发展的影响.
主要方法:
- 这是一项双盲多中心随机对照试验 (DOMInO试验),涉及2399名孕妇.
- 参与者从入学到出生时都接受了富含DHA的鱼油或安慰剂 (植物油).
- 使用爱丁堡产后抑郁症尺度评估母亲的抑郁症;用贝利婴儿和幼儿发展尺度评估18个月的儿童神经发育.
主要成果:
- 在分娩后6周或6个月,DHA和安慰剂组之间高抑郁症状发生率没有显著差异.
- 与对照组相比,DHA组的儿童在18个月后的认知或语言复合分数没有显著差异.
- 该试验的完成率很高,96.7%的女性完成了该研究.
结论:
- 在怀孕期间补充多可萨赫萨酸 (DHA) 并没有显著降低母亲的产后抑郁率.
- 怀孕期间的DHA摄入量没有提高儿童早期的认知或语言发育.
- 这些发现表明,DHA补充可能不会为母亲的心理健康或婴儿神经发育提供预期的好处.
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