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周围应用的含有Abeta的注射剂会诱导大脑β-氨酸粉症

Yvonne S Eisele1, Ulrike Obermüller, Götz Heilbronner

  • 1Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

Science (New York, N.Y.)
|October 23, 2010
PubMed
概括

将富含β-粉样蛋白 (β-粉样蛋白) 的提取物注射到大脑中会导致粉样蛋白症. 内注射也在小鼠中诱导了大脑β-氨基粉症,但需要更长的潜伏时间.

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...