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Updated: Jun 7, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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酶PIAS1通过表观遗传抑制来限制自然调节性T细胞分化

Bin Liu1, Samuel Tahk, Kathleen M Yee

  • 1Division of Hematology-Oncology, Department of Medicine, 11-934 Factor Building, 10833 Le Conte Avenue, University of California, Los Angeles, Los Angeles, CA 90095, USA. bliu@ucla.edu

Science (New York, N.Y.)
|October 23, 2010
PubMed
概括

SUMO E3酶PIAS1通过表观遗传沉默Foxp3促进体来限制调控性T细胞分化. Pias1的删除增强了调节性T细胞种群和自身免疫性疾病的抵抗力.

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