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Upf1 感知 3'UTR 长度,以增强 mRNA 衰变的潜力

J Robert Hogg1, Stephen P Goff

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. jh2721@columbia.edu

Cell
|October 30, 2010
PubMed
概括

无意中介衰变 (NMD) 降解了有缺陷的mRNA. 这项研究揭示了一种两步Upf1依赖的机制,用于降解具有长3'未翻译区域 (3'UTRs) 的mRNA,受翻译终结效率的影响.

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The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
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