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Updated: Jun 7, 2026

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
08:27

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

Published on: May 22, 2019

长非编码RNA,Jpx,是X染色体失活的分子开关

Di Tian1, Sha Sun, Jeannie T Lee

  • 1Howard Hughes Medical Institute, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Cell
|October 30, 2010
PubMed
概括

两个新的非编码RNAs,Jpx和Tsix,作为控制X染色体失活 (XCI) 的对立RNA开关. Jpx激活了Xist,而Tsix抑制了它,确保了女性的适当基因剂量.

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Quick Fluorescent In Situ Hybridization Protocol for Xist RNA Combined with Immunofluorescence of Histone Modification in X-chromosome Inactivation12:42

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