非A,非B型肝炎和型肝炎病毒的抗体
J W Mosley1, R D Aach, F B Hollinger
1Transfusion transmitted Viruses Study (TTVS) Group, National Institute of Health, Bethesda, Md.
JAMA
|January 5, 1990
概括
在20世纪70年代的样本中,对型肝炎病毒 (抗HCV) 抗体的测试确定了大约一半与输血相关的非A,非B型肝炎病例的原因. 一些剩余的病例可能涉及未识别的病毒.
科学领域:
- 病毒学 病毒学
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 非A,非B (NANB) 型肝炎是20世纪70年代输血后的一个重大问题.
- 在那个时代,NANB肝炎的致病原体仍然未被确定.
- 后来发现型肝炎病毒 (HCV) 是NANB肝炎的主要原因.
研究的目的:
- 追溯评估20世纪70年代储存的血清样本中对型肝炎病毒 (抗HCV) 抗体的存在.
- 确定HCV在该时期输血相关的NANB肝炎病例中的病因作用.
主要方法:
- 从输血传播病毒研究 (1970年代) 中储存的血清样本进行了抗HCV测试.
- 样本包括输血接受者和对照人群,其中一些人有记录的NANB肝炎或乙型肝炎病毒 (HBV) 感染.
主要成果:
- 在9名患有NANB肝炎的输血接受者中,有3人表现出抗HCV血清转化.
- 一位患有NANB肝炎和HBV感染的输血接受者出现了抗HCV血清转化.
- 对照对象和输血接受者感染HBV通常对抗HCV的测试结果为负,但有例外.
结论:
- 目前的抗HCV测试解释了大约50%的输血相关NANB肝炎病例的病因,特别是慢性肝炎病例.
- 没有抗HCV血清转换的NANB肝炎病例可能归因于其他尚未识别的病毒病原体.
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