富含果糖的饮料与女性中风风险
Hyon K Choi1, Walter Willett, Gary Curhan
1Section of Rheumatology and Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany St, Ste 200, Boston, MA 02118, USA. hchoius@bu.edu
JAMA
|November 12, 2010
概括
摄入富含果糖的饮料,如含糖的苏打水和汁,会增加女性的痛风风险. 这些饮料的摄入量较高与痛风发病率明显较高相关,突出了痛风发病的饮食因素.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 类风湿病学 类风湿病学
背景情况:
- 富含果糖的饮料,包括含糖的苏打水和汁,已知会提高血清尿酸水平.
- 尿酸升高是患上痛风的危险因素.
- 将果糖饮料消费与痛风发病率联系起来的前性数据有限.
研究的目的:
- 研究摄入富含果糖饮料和果糖与患痛风风险之间的关联.
- 这项研究集中在一大群女性身上.
主要方法:
- 利用了来自美国护士健康研究的数据,这是一项为期22年的前性队列研究 (1984-2006).
- 包括78,906名没有痛风病史的妇女.
- 评估饮料和果糖摄入量,使用经过验证的食物频率问卷.
主要成果:
- 在22年的时间里,确诊了778例痛风病例.
- 增加含糖苏打水的消费量独立地与更高的痛风风险有关 (每天≥2份的RR:2.39).
- 汁消费也显示出与痛风风险增加的显著关联 (每天≥2份的RR:2.42).
- 较高的整体果糖摄入量与痛风风险增加有关 (顶级五分之一的RR为1.62).
- 饮食软饮料与痛风风险没有关联.
结论:
- 富含果糖饮料的消费与女性中发生痛风的风险增加有关.
- 虽然相关性很明显,但由于女性的痛风发病率较低,总体人口的贡献可能很小.
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