欧洲的困难菌感染:一项医院调查
Martijn P Bauer1, Daan W Notermans, Birgit H B van Benthem
1Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, Bilthoven, Netherlands. m.p.bauer@lumc.nl
Lancet (London, England)
|November 19, 2010
概括
困难菌感染 (CDI) 在欧洲各不相同,非-027 PCR 核型是最常见的. 多国监测对于检测和控制这种重大医院感染至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 微生物学 微生物学
背景情况:
- 关于欧洲Clostridium difficile感染 (CDI) 的流行情况的数据有限.
- 需要确定在欧洲建立一个全面的CDI概述.
- 建立CDI诊断和监测能力是一个关键目标.
研究的目的:
- 确定欧洲医疗保健机构中Clostridium difficile感染的程度.
- 描述流行Clostridium difficile的PCR核型及其与患者结局的关联.
- 加强欧洲对CDI的监测和诊断能力.
主要方法:
- 欧洲34个国家的106个实验室的网络参与了这项研究.
- 测试了疑似CDI或医院获得的腹患者的便样本.
- 收集了临床数据和细菌分离物以进行详细分析和随访.
主要成果:
- CDI的发病率有显著的变化,其加权平均值为每10,000个患者日4.1.
- 确定了65种不同的PCR核型,其中014/020,001和078是最常见的.
- 高龄 (≥65岁) 和PCR核型018和056的感染与复杂的疾病结局有关.
结论:
- 除了之前强调的027之外的PCR核型在欧洲医院中普遍存在.
- 该研究强调了多国监控工作对于有效的CDI检测和控制至关重要.
- 调查结果强调需要对各种CDI菌株进行持续监测和有针对性的干预.
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