在Drosophila和Caenorhabditis中比较性别确定
1MRC Laboratory of Molecular Biology, Cambridge, UK.
Nature
|April 19, 1990
概括
果和线虫在性二态和剂量补偿方面具有相似的基因网络. 然而,它们的分子机制不同,这表明性别决定的演变方式不同.
科学领域:
- 遗传学 是一个遗传学.
- 发展生物学 发展生物学
- 进行比较基因组学.
背景情况:
- 控制性二态和剂量补偿的基因网络在果和线虫之间表现出组织上的相似性.
- 尽管保持了网络组织,但这些过程的分子基础在两种物种之间有很大差异.
研究的目的:
- 为了比较参与性二态化和果和线虫中剂量补偿的基因网络.
- 调查性决定和相关过程背后的分子机制的进化保存.
主要方法:
- 对基因表达模式的比较分析.
- 监管网络结构的生物信息分析.
- 检查保存和分离的遗传元素.
主要成果:
- 在基因网络的整体架构中观察到的相似之处,这些基因网络控制性二态和剂量补偿.
- 在果和线虫利用的特定分子参与者和调节元素中发现了显著的差异.
- 有证据表明,基本的发育过程,如性别决定,在分子水平上并不严格保存.
结论:
- 基因调节网络的进化可以通过不同的分子途径导致类似的功能结果.
- 发育过程,包括性别决定,显示出具有显著进化分歧的能力.
- 对比研究对于理解生物系统中保存的组织和机械的新奇性之间的相互作用至关重要.
相关概念视频
Background and Environment Affect Phenotype
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
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