在接受冠状动脉计算机断层扫描血管造影的患者中,对辐射剂量的个体化评估,256片扫描扫描
Kostas Perisinakis1, Ioannis Seimenis, Antonis Tzedakis
1Department of Medical Physics, Faculty of Medicine, University of Crete, Crete, Greece. perisina@med.uoc.gr
冠状动脉CT血管造影 (CCTA) 辐射风险是个性化的. 肺癌是最可能的损害,但风险在接受CCTA的患者中无效地增加了自然癌症的发生率.
科学领域:
- 医疗成像医学成像
- 辐射瘤学 辐射瘤学
- 心血管成像 - 心血管成像
背景情况:
- 冠状动脉CT血管学 (CCTA) 对辐射负担的现有数据主要依赖于有效剂量估计.
- 这项研究的重点是为接受CCTA的患者提供个性化的辐射剂量和癌症风险评估.
研究的目的:
- 在接受256片CCTA的患者中估计个性化辐射剂量和辐射诱导癌症的生命风险.
- 将这些风险与名义癌症风险进行比较.
主要方法:
- 模拟CCTA暴露在特定患者的发声化幻影上,以生成剂量沉积图像.
- 为放射敏感器官推导出正常化器官剂量,与患者的身体习惯相关.
- 在136名CCTA患者的肺,乳房和食道中确定吸收的剂量.
- 使用性别,年龄和器官特异性癌症风险因素估计可归因于生命的风险.
主要成果:
- 肺癌是最可能的辐射诱导的癌症损害后CCTA的两性.
- 放射性癌症的可归因的总预期寿命风险随着暴露时的年龄而降低.
- 预计未来ECG导向的CCTA的平均预期寿命可归因风险为女性24.9/100,000,男性7.3/100,000.
- 追溯ECG-gated CCTA的平均预期寿命可归因风险为女性的71.5/100,000和男性的31.4/100,000.
结论:
- 预计平均预期寿命的辐射诱导癌症的风险,从未来的ECG-gatedCCTA是最小的.
- 与临床患者队列中的自然癌症发病率相比,这些风险代表了无关紧要的增加.
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