欧洲血统作为非洲裔美国人心房动的危险因素
Gregory M Marcus1, Alvaro Alonso, Carmen A Peralta
1Electrophysiology Section, Division of Cardiology, University of California, San Francisco, 500 Parnassus Ave, MUE 434, San Francisco, CA 94143-1354, USA. marcusg@medicine.ucsf.edu
Circulation
|November 25, 2010
概括
欧洲血统增加了非洲裔美国人发展心房动 (AF) 的风险. 这一发现表明,遗传因素在种族群体之间的AF差异中起作用.
科学领域:
- 心血管遗传学 心血管遗传学
- 人口健康 人口健康
- 基因组学就是基因组学.
背景情况:
- 与白人相比,非洲裔美国人的心房发病率较低,尽管传统心房风险因素的患病率较高.
- 这种差异的根本原因,无论是遗传还是环境,仍然不清楚.
- 鉴于非洲裔美国人人口中不同程度的欧洲血统,本研究调查了欧洲血统作为AF的潜在独立风险因素.
研究的目的:
- 测试欧洲血统是非洲裔美国人中心房动 (AF) 的独立风险因素的假设.
- 量化欧洲血统的百分比与发展事件AF的风险之间的关联.
主要方法:
- 利用心血管健康研究 (CHS) 和社区动脉样硬化风险研究 (ARIC) 的数据,包括白人和非洲裔美国人参与者.
- 估计了非洲裔美国人的欧洲祖先,使用来自全基因组数组的祖先信息标记.
- 分析了发生的AF发展情况,并进行了元分析,以评估欧洲血统和AF风险之间的关系,并对混因素进行调整.
主要成果:
- 两组队伍的元分析显示,每增加10%的欧洲血统与13%的AF风险增加有关 (危险比:1.13).
- 在对潜在的混因素进行调整后,欧洲血统仍然是事件AF的重要预测因素,欧洲血统每增加10%的风险比率为1.17.
- 使用不同基因型阵列的独立分析产生了一致的结果,加强了这种关联.
结论:
- 欧洲血统被确定为发生性心房动 (AF) 风险的重要预测因素.
- 这些发现突显了遗传因素在理解非洲和欧洲血统的个人之间的AF风险差异的重要性.
- 对导致这些差异的特定遗传变异进行进一步的研究是有必要的.
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