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Updated: May 7, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Published on: July 17, 2019

通过MAP激酶通路的重新激活,COT驱动对RAF抑制的抗性

Cory M Johannessen1, Jesse S Boehm, So Young Kim

  • 1Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Nature
|November 26, 2010
PubMed
概括

通过向MAP3K8 (COT/Tpl2) 可以克服黑色素瘤对RAF抑制剂的抵抗. 这种激酶独立于RAF激活MAPK通路,为BRAF突变黑色素瘤患者提供新的治疗策略.

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