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Updated: May 7, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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黑色素瘤通过RTK或N-RAS上调获得对B-RAF (V600E) 抑制的抗性

Ramin Nazarian1, Hubing Shi, Qi Wang

  • 1Division of Dermatology/Department of Medicine, UCLA's Jonsson Comprehensive Cancer Center, 52-121 CHS, Los Angeles, California 90095-1750, USA.

Nature
|November 26, 2010
PubMed
概括

黑色素瘤对像PLX4032这样的BRAF抑制剂的耐药性源于PDGFRB上调或NRAS突变,而不是二次BRAF突变. 针对这些途径为BRAF抑制剂耐药黑色素瘤提供了新的治疗策略.

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