一个转录调节器的体内降解:酵母的α2抑制剂

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Updated: May 12, 2026

Reporter-based Growth Assay for Systematic Analysis of Protein Degradation
07:47

Reporter-based Growth Assay for Systematic Analysis of Protein Degradation

Published on: November 6, 2014

M Hochstrasser1, A Varshavsky

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Cell
|May 18, 1990
PubMed
概括

调节性蛋白质,如酵母α2抑制剂,需要代谢不稳定才能发挥作用. 这项研究揭示了二重降解信号和α2蛋白循环的途径,使蛋白质复合体中的选择性亚单元替代成为可能.

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