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A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
Published on: February 17, 2023
在实验性心脏动模型中,对心室动的易感性显著变化
Alawi A Alsheikh-Ali1, Christopher Madias, Stacey Supran
1Cardiac Arrhythmia Center, Division of Cardiology, Tufts Medical Center, 800 Washington St, Box 197, Boston, MA 02111, USA.
Circulation
|December 4, 2010
概括
胸部动荡 (commotio cordis) 或由于胸部打击而引起的突然心脏骤停,由于个体的易感性而很罕见. 一些动物表现出由于胸部冲击而对心室动 (VF) 的高度脆弱性,这表明人类也有类似的敏感性.
科学领域:
- 心脏病学 心脏病学
- 运动医学 运动医学
- 生理学 生理学 生理学
背景情况:
- 心脏前部的打击可以诱导心室动 (VF),这是一个罕见的事件,称为心脏动荡.
- 虽然冲击因素至关重要,但假设个人易感性会影响心脏动荡的发生.
研究的目的:
- 为了评估个体动物对VF诱导的敏感性,使用commotio cordis模型.
- 为了确定与胸壁冲击后VF易感性相关的动物特征.
主要方法:
- 对 139 头未成年猪进行了回顾性分析,这些猪受到了胸壁的打击.
- 在心脏再极化脆弱窗口期间,对心脏轮产生了冲击.
- 评估了个体对VF和相关生理参数的敏感性.
主要成果:
- 在1274个总体冲击中,28%诱导了VF,个体动物易感度有显著的变化.
- 大多数动物需要<30%的打击来诱导VF;只有5%的动物持续发展VF (>80%的冲击).
- 左心室压力,QRS持续时间和QTc变化是风险的显著相关因素.
结论:
- 猪表现出广泛的个人易受冲击诱导的VF的脆弱性,少数人非常容易受到影响.
- 心脏脱极化和再极化中的微妙异常可能是这种易感性的基础.
- 个体敏感性可以解释人体内心脏动荡的罕见性.
相关概念视频
Mechanism of Cardiac Arrhythmias
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Disturbances in Heart Rhythm
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Electrophysiology of Normal Cardiac Rhythm
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
Dysrhythmias III: Characteristics of Dysrhythmias
Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per minute.
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
