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相关概念视频

Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action01:17

Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action

Nondepolarizing neuromuscular blockers induce paralysis by competitively blocking nicotinic acetylcholine receptors at the muscle end plate. Examples include pancuronium, mivacurium, vecuronium, and rocuronium. These quaternary ammonium derivatives are administered intravenously, are poorly absorbed, and are excreted via the kidneys.
Competitive antagonists prevent acetylcholine from binding to its receptor, inhibiting membrane depolarization. Without conformational changes or intrinsic...

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Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Published on: July 14, 2021

使用磁纳米粒子进行自主变色.

Lilei Yu1, Benjamin J Scherlag, Kenneth Dormer

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, China.

Circulation
|December 8, 2010
PubMed
概括

携带神经毒素的超偏磁纳米颗粒被开发为向和抑制心房结节性 (GP) 活动,为自主性剥离提供了一种新的方法. 这种方法成功地减少了GP功能,可能治疗心房动.

科学领域:

  • 心血管研究研究心血管研究
  • 纳米技术在医学中的应用
  • 自主神经系统的自主神经系统

背景情况:

  • 之前的研究表明,切除主要心房状 (GP) 可以抑制心房动.
  • 耳前状腺在调节心脏自主功能方面发挥着至关重要的作用.

研究的目的:

  • 合成和评估超偏磁纳米颗粒 (MNP) 用于针对性地向心房全科医生提供药物.
  • 评估携带神经毒剂 (N-异甲胺单体[NIPA-M]) 的MNP在抑制GP活动及其对心房的影响方面的疗效.

主要方法:

  • 合成了超偏磁铁氧化物 (Fe(3) O(4)) 核心外纳米颗粒与热敏水凝和NIPA-M.
  • 给狗的MNP是通过直接注射到前右GP (ARGP) 或针对右下GP (IRGP) 的冠心内输液.
  • 通过测量对高频刺激的鼻腔速度和心室速度减缓反应来评估GP功能,IRGP使用磁性准.

主要成果:

  • 注射到ARGP中的MNP显著抑制了高频刺激诱导的鼻率减缓 (40%至21%,P=0.006),并增加了心房的诱导值.
  • 冠内MNP有效抑制IRGP功能 (心室速度减缓减少57%至20%,P=0.002),但没有影响ARGP功能.
  • 组织学分析证实MNP局部在IRGP,而不是ARGP.

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Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
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Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

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Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
08:26

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结论:

  • 携带NIPA-M的静脉内注射MNP可以通过磁性向IRGP,通过局部NIPA-M释放减少GP活动.
  • 这种有针对性的药物输送系统代表了自主性消毒的新型血管内方法.
  • 这些发现表明,通过对心脏自主神经系统的有针对性的调节来管理心房动等疾病的潜在新策略.