证据表明双链核酸的近共振电荷转移机制
Ravindra Venkatramani1, Kathryn L Davis, Emil Wierzbinski
1Department of Chemistry, Duke University, Durham, North Carolina 27708, USA.
Journal of the American Chemical Society
|December 15, 2010
概括
短核酸 (PNA) 复合体中的电荷转移是近共振的,而不仅仅是超交换. 这一发现得到了电化学和计算研究的支持,可以更好地解释PNA电荷传输机制的实验数据.
科学领域:
- 分子生物学分子生物学
- 纳米技术 纳米技术
- 物理化学 物理化学
背景情况:
- 电荷转移对于分子电子学至关重要.
- 核酸 (PNA) 是DNA模仿物,具有潜在的电子应用.
- 了解PNA双层车中的收费运输机制对于其发展至关重要.
研究的目的:
- 为了研究短核酸 (PNA) 复合体中的电荷转移机制.
- 确定现有模型是否足够解释实验观测.
- 提出一个更全面的模式,用于在PNA双层的负载运输.
主要方法:
- 电化学测量 电化学测量
- 扫描道显微镜断路结 (STM-BJ) 研究研究.
- 计算分析 计算分析
主要成果:
- 电荷转移速率和导电性与基的氧化潜力相关.
- purin 基在 PNA 双重体内的位置不会显著影响电荷转移.
- 一个简单的超级交换模型无法解释实验结果,特别是关于关氨酸含量.
- 一种接近共振的电荷转移模型,结合了超交换和跳跃,成功地合理化了所有实验发现.
结论:
- 短PNA双重机中的电荷转移通过近共振机制运行.
- 这种机制调和了实验数据,而简单的模型无法做到这一点.
- 这些发现促进了对合成核酸中电荷传输的理解,并为潜在的电子应用提供了帮助.
相关概念视频
Nucleic Acid Structure
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
DNA Structure
DNA has a double-helix structure. The...
Peptide Bonds
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
Nucleic Acids
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic acids
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
DNA as a Genetic Template
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
The DNA Helix
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...


