芯可点击的PEG-branch-azide双价瓶刷聚合物通过ROMP:通过接种和点击到
Jeremiah A Johnson1, Ying Y Lu, Alan O Burts
1Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, California 91125, USA.
Journal of the American Chemical Society
|December 15, 2010
概括
研究人员使用点击化学创建了新的分支纳米结构. 这些结构有效地将癌症药物多克索鲁比 (DOX) 传递给细胞,在紫外线光激活后证明了治疗效果.
科学领域:
- 聚合物化学 聚合物化学
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 点击化学和高效的聚合使得新的纳米结构合成成为可能.
- 开发精确设计的纳米载体对于有针对性的药物输送至关重要.
- 以前的方法缺乏易于合成具有药物结合能力的分支纳米结构.
研究的目的:
- 为了合成一个新的类别的可点击的,分支的纳米结构:聚乙烯糖醇 (PEG) -分支-亚酸二价刷聚合物.
- 通过点击化学将这些纳米结构与多克索鲁比 (DOX) 功能化.
- 为了评估DOX载荷纳米结构的治疗疗效.
主要方法:
- 一个norbornene-PEG-化物宏观分子的通过移植环开放的转化聚合.
- 化-化交换引入化组.
- 铜催化亚酸-酸环添加 (CuAAC) 用于DOX结合.
- 用于药物释放和体外癌细胞研究的紫外线光解.
主要成果:
- 易于合成PEG-branch-azide双价刷聚合物,类似于单分子微粒.
- 定量CuAAC对照可分离的DOX-衍生物与亚核在各种纳米尺寸 (6-50 nm) 的量子合.
- 紫外线诱导的活性DOX从纳米结构中的释放,显示对人类癌细胞的治疗效果.
结论:
- 开发的双价刷聚合物作为纳米结构合成和药物结合的多功能平台.
- 点击化学方法可以实现高效且独立于尺寸的药物加载.
- 这些纳米结构显示出针对性癌症治疗的显著潜力,具有光触发药物释放.
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