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Updated: Jun 6, 2026

Quantification of γH2AX Foci in Response to Ionising Radiation
06:53

Quantification of γH2AX Foci in Response to Ionising Radiation

Published on: April 6, 2010

H2AX阻止了CtIP介导的DNA末端切除和G1期淋巴细胞的异常修复

Beth A Helmink1, Anthony T Tubbs, Yair Dorsett

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Nature
|December 17, 2010
PubMed
概括

希斯H2AX防止在发育中的淋巴细胞中过早的DNA末端切除. 在没有H2AX的情况下,CtIP处理DNA断裂,导致在抗原受体基因组装过程中的基因组不稳定性和染色体缺失.

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