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Updated: Jun 22, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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Published on: April 21, 2015

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在转基因小鼠中,IL-4诱导过敏类炎症性疾病,并改变T细胞的发育

R I Tepper1, D A Levinson, B Z Stanger

  • 1Department of Genetics, Harvard Medical School, Boston, Massachusetts.

Cell
|August 10, 1990
PubMed
概括

在小鼠中改变介质素-4 (IL-4) 基因表达导致IgE增加和过敏眼睛炎症. 这种细胞因子失调也影响了T细胞的成熟,突显了IL-4在过敏疾病中的作用.

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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice07:34

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T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...