在一个古老的电路中插入一层新的转录调节层
Lauren N Booth1, Brian B Tuch, Alexander D Johnson
1Department of Microbiology and Immunology and Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA.
Nature
|December 18, 2010
概括
基因调节网络的重新连接通过添加新的控制层创造了进化新性. 这项研究揭示了Kluyveromyces lactis中间接基因调节如何影响交配行为.
科学领域:
- 进化生物学是进化的生物学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 基因调节网络 (GRNs) 对于进化新性至关重要.
- GRN重新布线可以引入新的转录控制层.
- 了解这些变化为进化过程提供了洞察力.
研究的目的:
- 为了研究一个特定的GRN重新连接事件在ascomycete酵母.
- 了解转录控制的变化如何影响细胞行为.
- 探索酵母中的交配电路的进化历史.
主要方法:
- 对比基因组学和遗传学分析.
- 在Saccharomyces cerevisiae,Kluyveromyces lactis和Candida albicans中进行实验操纵.
- 对基因表达模式和调节性蛋白相互作用的分析.
主要成果:
- 确定了一个重组事件,其中直接的基因调节被通过K. lactis.中通过Rme1间接控制取代.
- 祖先的交配电路逻辑被保存下来,但产生了一个新的表型.
- 通过Rme1.1,K. lactis将营养信号整合到交配决定中.
结论:
- GRN重新布线,特别是监管层次的插曲,是进化创新的重要机制.
- 间接基因调节的进化可以导致新的细胞行为和适应.
- 这项研究为了解古代电路如何被修改以产生新功能提供了一个模型.
相关概念视频
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Transcription
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Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
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Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
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Transcription
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...


