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通过ZRF1对多抑制基因的转录激活

Holger Richly1, Luciana Rocha-Viegas, Joana Domingues Ribeiro

  • 1Centre de Regulació Genòmica (CRG)/UPF, 08003 Barcelona, Spain.

Nature
|December 24, 2010
PubMed
概括

在细胞分化过程中,ZRF1蛋白质结合到无处不在的基因组H2A,取代多抑制复合体1 (PRC1),以激活基因转录. 这种表观遗传机制是细胞命运决定的关键.

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