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Updated: May 10, 2026

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
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Published on: March 3, 2015

c-Jun N-终端酸化阻碍了Mbd3/NuRD抑制器复合物的招募

Cristina Aguilera1, Kentaro Nakagawa, Rocio Sancho

  • 1Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Nature
|January 4, 2011
PubMed
概括

激活蛋白1 (AP-1) 的转录受c-Jun的调节. 不酸化的c-Jun通过Mbd3招募NuRD抑制复合体,抑制目标基因表达. 基因酸化缓解了这种抑制,促进了基因转录.

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