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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Pre-mRNA Processing: Modification of pre-mRNA Ends01:35

Pre-mRNA Processing: Modification of pre-mRNA Ends

In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps the cell...
Chromatin Structure and RNA Splicing02:41

Chromatin Structure and RNA Splicing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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相关实验视频

Updated: May 13, 2026

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
08:50

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

在替代性mRNA前剪接中的表观遗传学.

Reini F Luco1, Mariano Allo, Ignacio E Schor

  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|January 11, 2011
PubMed
概括
此摘要是机器生成的。

替代拼接对于蛋白质多样性至关重要,越来越多地被理解为由表观遗传因素 (如染色质结构) 调节. 这表明表观遗传学不仅影响基因表达,而且影响RNA拼接结果.

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Last Updated: May 13, 2026

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
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Published on: May 14, 2020

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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Published on: May 5, 2023

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
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Published on: October 28, 2025

科学领域:

  • 分子生物学分子生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 基因组学就是基因组学.

背景情况:

  • 替代拼接是产生真核生物中的蛋白质多样性的关键机制.
  • 传统的研究重点是RNA元素和拼接因子.
  • 新出现的证据强调了染色质结构在拼接调节中的作用.

研究的目的:

  • 探索染色质结构和基因组修饰对替代拼接的影响.
  • 将表观遗传调节纳入替代拼接控制的理解.

主要方法:

  • 分析RNA序列元素和拼接因子.
  • 研究染色质修饰对拼接模式的影响.

主要成果:

  • 染色质结构和基因素修饰在调节替代拼接方面发挥着重要作用.
  • 表观遗传机制是控制基因如何结合的不可或缺的一部分.

结论:

  • 表观遗传调节超出了基因表达范围,影响了替代拼接.
  • 了解拼接的表观遗传控制对于理解发育和疾病至关重要.