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Quantifying Agonist Activity at G Protein-coupled Receptors
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激动剂和部分激动剂对β(1) -上腺素受体的作用的结构基础

Tony Warne1, Rouslan Moukhametzianov, Jillian G Baker

  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

Nature
|January 14, 2011
PubMed
概括

结构洞察力揭示了不同的配体如何激活β-上腺素受体 (βARs). 完全激动剂与部分激动剂不同,结合关键的血清残留物,解释了喘和高血压等疾病的多种治疗作用.

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