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旧世界和大猿的伪自体边界的演变
1Imperial Cancer Research Fund, Lincoln's Inn Fields, London, England.
Cell
|November 30, 1990
概括
在大猿和旧世界子的分歧后,在Y染色体上的哺乳动物伪自体边界插入的Alu重复元素. 这种插入并没有创建边界,而是发生在先前存在的边界上,保持性别染色体同质性.
科学领域:
- 遗传学和进化生物学
- 哺乳动物的性别染色体进化 染色体进化
背景情况:
- 哺乳动物的性别染色体包括性别特异性和伪自体区域.
- 伪自体区域经历重组,而性别特定区域则没有.
- 伪自体边界标志着重组的中心极限.
研究的目的:
- 为了研究Y染色体上的伪自体边界的进化史.
- 确定Alu重复元素在这个边界形成中的作用.
主要方法:
- 性染色体序列的比较进化分析.
- 对Y染色体边界的Alu重复元素存在的检查,跨越不同的灵长类动物血统.
主要成果:
- 一个Alu重复元素存在于Y染色体的伪自体边界在大猿,但在旧世界子中不存在.
- 性染色体之间的同质性是通过再组合端粒到Alu插入部位在两种谱系中保持的.
- 在旧世界和大猿血统的分歧后,在现有的边界上插入了Alu元素.
结论:
- 重复元素不是当前伪自体边界的原因.
- 边界早于Alu插入,这发生在后系分歧.
- 在侧面区域的重组对于在灵长类动物进化过程中保持性染色体同质性至关重要.
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