血β-粉样蛋白水平和认知储备与随后的认知衰退的相关性
Kristine Yaffe1, Andrea Weston, Neill R Graff-Radford
1Department of Psychiatry, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA. kristine.yaffe@ucsf.edu
JAMA
|January 20, 2011
概括
较低的血β-粉样蛋白42/40水平与没有痴呆症的老年人认知能力下降的增加有关. 这种关联在认知储备较低的个体中更为明显,突出了神经退行性疾病的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物研究 生物标志物研究
背景情况:
- 关于血β-粉样蛋白 (Aβ) 水平与认知衰退之间的关联存在矛盾的结果,特别是在非痴呆症老年人中.
- 以前的研究主要集中在事件痴呆症上,而不是在没有痴呆症的情况下认知衰退.
研究的目的:
- 为了研究血Aβ水平 (Aβ42和Aβ42 / 40的比率) 与老年人9年的认知衰退之间的关联.
- 为了确定认知储备是否改变了血Aβ水平和认知衰退之间的关系.
主要方法:
- 来自健康ABC研究的997名黑人和白人社区老年人 (平均年龄74.0岁) 的前性观察研究.
- 测量了血Aβ42和Aβ42/40水平,并使用修改的迷你精神状态检查 (3MS) 评估认知功能,在10年内反复进行.
- 进行了统计分析,以检查关联,调整共变量,并评估与认知储备 (教育,识字,APOE ε4状态) 措施的相互作用.
主要成果:
- 较低的血Aβ42/40水平与9年来更大的认知衰退显著相关 (P < .001).
- 这一关联在调整多个共同变量并排除患有发作性痴呆症的参与者后仍然显著.
- 认知储备措施,包括教育,识字和APOE ε4状态,显著改变了相关性 (P = .004对于教育,P = .005对于识字,P = .02对于APOE ε4). 具体来说,较低的Aβ42/40与认知衰退之间的关联在认知储备较低的个体中更为强烈.
结论:
- 较低的血Aβ42/40水平是9年期间在非痴呆症老年人中更大的认知衰退的重要预测因素.
- 血Aβ42/40对认知衰退的影响受到认知储备的缓解,具有较低储备的个体经历了更明显的衰退.
- 血Aβ水平可以作为一种有价值的生物标志物,用于识别患有认知恶化风险较高的老年人,特别是考虑到他们的认知储备.
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