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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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相关实验视频

Updated: Jun 5, 2026

A Method to Study de novo Formation of Chromatin Domains
07:34

A Method to Study de novo Formation of Chromatin Domains

Published on: August 23, 2019

聚合物复合物PRC2及其生命中的标志

Raphaël Margueron1, Danny Reinberg

  • 1Institut Curie, 26 Rue d'Ulm, 75005 Paris, France.

Nature
|January 21, 2011
PubMed
概括

多组蛋白质,包括多抑制复合体2 (PRC2),调节基因表达和染色质结构. 最近的研究强调了非编码RNA.

科学领域:

  • 表观遗传学和基因调控
  • 染色体生物学 染色体生物学
  • 发育生物学 发展生物学

背景情况:

  • 多组 (PcG) 蛋白质是维持细胞身份的关键表观遗传调节剂.
  • 两个主要的哺乳动物PcG复合体,PRC1和PRC2,调节色素结构.
  • PRC2催化了基因组H3氨酸27甲基化,影响了基因表达和细胞可塑性.

研究的目的:

  • 阐明聚合物镇压复合物2 (PRC2) 的调节机制和功能作用.
  • 调查非编码RNA在PRC2招募和功能中的参与.

主要方法:

  • 关于PRC2功能和调节的最新研究的综述.
  • 对PRC2-介导的染色质修饰的实验数据的分析.
  • 研究与PRC2.2.的非编码RNA相互作用.

主要成果:

  • 在细胞分化,身份,增殖和干细胞可塑性方面,PRC2起着至关重要的作用.
  • 非编码RNAs是新发现的关键参与者在招募PRC2以向基因.
  • PRC2活动对于维持发育基因表达模式至关重要.

结论:

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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

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Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

  • PRC2是一种具有多种生物功能的中央表观遗传调节器.
  • 非编码RNA介导的招募扩大了对PRC2调控的理解.
  • 针对PRC2及其监管途径提供了潜在的治疗途径.