印记Grb10的亲代基因具有独特的生理和行为功能
Alastair S Garfield1, Michael Cowley, Florentia M Smith
1Department of Biology & Biochemistry and Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Nature
|January 29, 2011
概括
印制的基因Grb10调节社会行为,其在大脑中的父性表达增加了社会主导地位. 失去其在外围的母体表达导致胎儿和胎盘过度生长.
科学领域:
- 遗传学 遗传学 是一个
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
背景情况:
- 印记基因来自单个亲代基因的表达,对哺乳动物发育和产后功能至关重要.
- 不平等的父母等位基因代表可以推动印记基因的进化,调节社会行为.
- Grb10是一种印记基因,编码了一个参与信号通路的细胞内适应蛋白.
研究的目的:
- 为了研究Grb10在大脑中印记表达的作用及其对社会行为的影响.
- 确定Grb10是否是第一个印制的调节社会行为的基因.
- 探索Grb10的双重组织特异性印记表达及其独特的生理效应.
主要方法:
- 从胎儿生命到成年时,对大脑中的Grb10表达的分析.
- 在小鼠中移除父亲的Grb10表达.
- 观察和量化社会行为,包括统治和allogrooming.
- 在失去母亲的Grb10表达之后,评估胎儿和胎盘的生长.
主要成果:
- 在整个发育过程中和成年期内,Grb10从大脑中的父方等位基因表达出来.
- 父亲的Grb10表达的消去导致了社会主导地位的增加和allogrooming.
- 失去外周表达的母体Grb10等位基因导致胎儿和胎盘显著过度生长.
- Grb10表现出来自两个亲代基因的独特的组织特异性印记表达.
结论:
- Grb10是第一个识别的印记基因,它调节社会行为.
- Grb10通过组织特异的亲代基因表达独特地影响不同的生理过程,包括胎儿生长和成人社会行为.
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