在癌症患者中使用贝瓦齐祖马布治疗相关的死亡率:元分析
Vishal Ranpura1, Sanjaykumar Hapani, Shenhong Wu
1Department of Medicine, Stony Brook University Cancer Center, 9447 SUNY, Stony Brook, NY 11794, USA.
JAMA
|February 3, 2011
概括
在化疗中添加贝瓦齐祖马布会增加癌症患者致命不良事件 (FAE) 的风险. 这一元分析证实了bevacizumab的存在.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 在接受贝瓦齐祖马布 (血管生成抑制剂) 与化疗相结合的癌症患者中报告了致命的不良事件 (FAE).
- 贝瓦西祖马布对与治疗相关的死亡率的确切贡献尚不清楚.
研究的目的:
- 进行随机对照试验 (RCT) 的系统审查和元分析.
- 为了确定与癌症治疗中贝瓦齐祖马布相关的FAE的总体风险.
主要方法:
- 在PubMed,EMBASE和Web of Science数据库以及ASCO会议摘要 (1966-2010) 中进行系统搜索.
- 包括前性RCT,比较贝瓦齐祖马布加化疗/生物疗法与单独的化疗/生物疗法.
- 使用固定或随机效应模型计算总结发病率和相对风险 (RRs).
主要成果:
- 分析包括来自16个RCT的10,217名患者,涉及各种高级固体瘤.
- 贝瓦西祖马布FAE的总发病率为2.5% (95% CI,1.7%-3.9%).
- 贝瓦西祖马布显著增加了FAE风险 (RR=1.46,P=.01),特别是与税或剂 (RR=3.49).
- 常见的FAE包括出血,中性衰竭和胃肠道穿孔.
结论:
- 贝瓦西祖马布,当与化疗或生物疗法相结合时,与治疗相关的死亡率增加有关.
- FAE的风险因使用的特定化疗剂而异.
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