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Updated: Jun 4, 2026

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1
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A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1

Published on: March 18, 2017

端粒RNA四重复-亚克里丁连接体识别的结构基础

Gavin W Collie1, Silvia Sparapani, Gary N Parkinson

  • 1CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London, United Kingdom.

Journal of the American Chemical Society
|February 5, 2011
PubMed
概括

端粒重复含有RNA (TERRA) 形成四重复结构. 晶体结构揭示了独特的RNA四重复-阿克里丁结合,涉及特定的循环构造,与DNA四重复不同,为治疗设计提供了洞察力.

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RNA Structure01:19

RNA Structure

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Different Types of RNA Have the Same Basic Structure
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RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
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Transfer RNA Synthesis

One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
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Nucleic Acid Structure

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DNA Base Pairing

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Telomeres and Telomerase

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