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相关概念视频

Propagation of Action Potentials01:23

Propagation of Action Potentials

The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Action Potentials01:41

Action Potentials

Overview
Action Potential: Phases of Stimulation01:28

Action Potential: Phases of Stimulation

The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
Action Potential01:14

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Action Potential01:14

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Generation of Action Potential in Skeletal Muscles01:24

Generation of Action Potential in Skeletal Muscles

Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the cell's...

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相关实验视频

Updated: Jun 4, 2026

Voltage-sensitive Dye Recording from Axons, Dendrites and Dendritic Spines of Individual Neurons in Brain Slices
12:51

Voltage-sensitive Dye Recording from Axons, Dendrites and Dendritic Spines of Individual Neurons in Brain Slices

Published on: November 29, 2012

在轴突导电过程中作用电位调制.

Takuya Sasaki1, Norio Matsuki, Yuji Ikegaya

  • 1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan.

Science (New York, N.Y.)
|February 5, 2011
PubMed
概括
此摘要是机器生成的。

动作电位 (AP) 沿着轴突改变形状,与经典观点相反. 这种由局部因素影响的波形调制会影响突触传输,并可能使轴突计算成为可能.

更多相关视频

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises
13:56

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises

Published on: January 18, 2011

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
11:07

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation

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相关实验视频

Last Updated: Jun 4, 2026

Voltage-sensitive Dye Recording from Axons, Dendrites and Dendritic Spines of Individual Neurons in Brain Slices
12:51

Voltage-sensitive Dye Recording from Axons, Dendrites and Dendritic Spines of Individual Neurons in Brain Slices

Published on: November 29, 2012

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises
13:56

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises

Published on: January 18, 2011

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
11:07

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation

Published on: May 11, 2020

科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学
  • 神经生理学 神经生理学

背景情况:

  • 传统的理解假定在轴突树沿线均的动作电位 (AP) 传播.
  • 这种观点假设AP在轴突传输过程中不会改变波形.

研究的目的:

  • 为了调查行动电位 (AP) 在轴突传播过程中是否经历波形调制.
  • 探索AP波形变化对突触传输的功能后果.

主要方法:

  • 使用光补丁管道用于海马CA3金字塔神经元轴突分支的APs的体外记录.
  • 应用谷氨酸和氨酸A(1) 受体对抗剂局部到轴突轴.
  • 在周边神经细胞中进行脱,以评估神经细胞与神经元的相互作用.

主要成果:

  • 轴突AP波形在局部应用谷氨酸和腺氨酸A(1) 受体对抗剂时扩大.
  • 天体细胞脱,导致离子转移性谷氨酸受体激活,也扩大了APs.
  • 扩大APs导致预突触的增加和突触传输的增强.

结论:

  • 动力电位在轴突沿线受到局部波形调制,挑战了统一传播的经典观点.
  • 这种AP修饰,受天体细胞活动和局部神经递质释放的影响,可以改变突触疗效.
  • 局部AP调制可能代表轴突计算的机制,利用轴突电线几何.