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相关概念视频

Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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相关实验视频

Updated: Jun 4, 2026

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

鱼中的甲状腺候选物.

Baubak Bajoghli1, Peng Guo, Narges Aghaallaei

  • 1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D-79108 Freiburg, Germany.

Nature
|February 5, 2011
PubMed
概括
此摘要是机器生成的。

兰普雷幼虫具有类似于胸腺的结构,称为胸腺体,对于开发T型淋巴细胞至关重要. 这些甲状腺是变性淋巴细胞受体 (VLR) 基因组合的地点,类似于椎动物的甲状腺功能.

更多相关视频

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm
13:43

Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm

Published on: June 17, 2018

相关实验视频

Last Updated: Jun 4, 2026

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm
13:43

Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm

Published on: June 17, 2018

科学领域:

  • 免疫学 免疫学 免疫学
  • 进化生物学 进化生物学
  • 脊椎动物动物学 脊椎动物动物学

背景情况:

  • 没有的脊椎动物 (鱼和鱼) 拥有独特的免疫系统,与有的脊椎动物不同.
  • 灯利用体质多样化的可变淋巴细胞受体 (VLR) 而不是免疫球蛋白进行抗原识别.
  • 在没有的鱼类中,用于淋巴细胞发育的主要淋巴体器官仍然在很大程度上没有表征.

研究的目的:

  • 为了研究鱼中原发性淋巴体器官的存在和功能.
  • 确定T型淋巴细胞发育和VLR基因多样化的潜在地点.

主要方法:

  • 在幼虫中识别和组织学分析淋巴上皮结构.
  • 在已识别的结构中对FOXN1,CDA1和VLRA的基因表达分析.
  • 检测非功能VLRA基因组合.

主要成果:

  • 在鱼状细丝中发现了分立的状结构,称为thymoids.
  • 蒂莫体表现出FOXN1,CDA1和VLRA的共同表达,这表明了T型细胞的发展.
  • 非功能性VLRA基因组合在甲状腺动物中普遍存在,支持它们在VLR多样化中的作用.

结论:

  • 兰普雷甲状腺体作为主要的淋巴体器官,类似于椎动物的甲状腺体.
  • 这些发现突出了脊椎动物血统中适应性免疫的发展中的保留特征.
  • 这项研究加深了我们对早期脊椎动物免疫系统进化的理解.