限制性消除饮食对患有注意力缺陷多动症儿童行为的影响 (INCA研究):一项随机对照试验
Lidy M Pelsser1, Klaas Frankena, Jan Toorman
1ADHD Research Centre, Eindhoven, Netherlands. lmjpelsser@adhdresearchcentre.nl
Lancet (London, England)
|February 8, 2011
概括
限制性消除饮食显著改善了儿童的多动症症状. 然而,根据IgG水平重新引入食品并没有防止症状复发,这表明这种诊断方法不可靠.
科学领域:
- 儿童营养学 儿童营养学
- 行为科学 行为科学
- 临床试验 临床试验
背景情况:
- 注意力缺陷多动症 (ADHD) 研究主要集中在特定的患者子组,涉及饮食干预.
- 在未经选择的ADHD人群中调查饮食行为联系至关重要.
研究的目的:
- 为了检查与ADHD诊断的未选组儿童的饮食和行为之间的关系.
- 评估限制性消除饮食和基于IgG的食物挑战在管理ADHD症状中的有效性.
主要方法:
- 一个随机对照试验 (INCA研究) 涉及一个开放阶段 (消除饮食与健康饮食),随后是双盲交叉食品挑战阶段.
- 患有多动症的4-8岁儿童被随机分配. 受访者经历了高IgG或低IgG食物的挑战.
- 主要终点包括多动症评分尺度 (ARS) 和简称康纳斯尺度 (ACS) 成绩的变化.
主要成果:
- 与对照组相比,限制性消除饮食组在ARS和ACS得分上显示出显著的改善 (p<0.0001).
- 在挑战阶段,63%的受试者经历了ADHD症状的复发,不管IgG水平如何.
- 在这两个阶段都没有报告任何不良事件.
结论:
- 严格监督的限制性消除饮食对于评估食物引起的ADHD是有效的.
- 基于IgG血液测试的饮食处方不建议,因为缺乏预防症状复发的有效性.
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