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列出和移植具有先天性心脏病的成年人
Ryan R Davies1, Mark J Russo, Jonathan Yang
1Falk Cardiovascular Research Building, 300 Pasteur Drive, Palo Alto, CA 94305-5407, USA. rdavies2@stanford.edu
Circulation
|February 9, 2011
概括
成年先天性心脏病 (CHD) 患者在心脏移植后面临高早期死亡率,但与其他接受者相比,他们实现了类似的长期存活率. 机械循环支持并没有改善CHD患者的等待名单生存率.
科学领域:
- 心脏病学 心脏病学
- 移植医学 移植医学
- 成年人的先天性心脏病
背景情况:
- 越来越多的成年人患有先天性心脏病 (CHD),需要进行心脏移植.
- 关于成年心血管疾病患者移植后生存结果的有限数据.
研究的目的:
- 评估心脏移植后患有心脏病的成年患者的存活率.
- 为了比较CHD和非CHD患者在等待名单和移植后的结果.
主要方法:
- 对41,849名成年患者的回顾性分析,这些患者被列入初级心脏移植 (1995-2009) 清单.
- 1035名心血管疾病患者与40814名非心血管疾病患者的比较.
- 根据先前的胸腔切除术 (重新手术与非重新手术) 进行子组分析.
主要成果:
- 与非心脏病患者相比,先天性心脏病患者的早期死亡率较高,但相当于10年总生存率.
- 机械心室辅助并没有改善CHD患者的等待名单生存率.
- 心脏病患者年轻,体重指数较低,移植时伴随疾病较少.
结论:
- 患有先天性心脏病的成年人经历了高的30天死亡率,但心脏移植后的晚期存活率有所改善.
- 机械循环辅助在心血管疾病患者的等待名单上没有生存益处.
- 复杂的重新手术和手术前的健康状况可能会对结果产生影响.
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