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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
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9p21 与冠状动脉疾病相关的DNA变异会损害干扰素-γ信号响应

Olivier Harismendy1, Dimple Notani, Xiaoyuan Song

  • 1Department of Pediatrics and Rady's Children's Hospital, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA.

Nature
|February 11, 2011
PubMed
概括

9p21区域的遗传变异与冠状动脉疾病 (CAD) 和2型糖尿病有关. 这项研究确定了9p21中的增强剂,揭示了风险等位基因如何破坏STAT1结合并影响对炎症反应的基因表达.

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