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在上腺产生阿尔多素的腺瘤和遗传性高血压中的K+通道突变

Murim Choi1, Ute I Scholl, Peng Yue

  • 1Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

Science (New York, N.Y.)
|February 12, 2011
PubMed
概括

KCNJ5基因的突变通过破坏 (K+) 通道功能,导致严重的高血压. 这导致 (Na+) 流入量增加,推动上腺瘤中的阿尔多素生产和细胞生长.

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