欧洲先天性心脏缺陷:患病率和围产期死亡率,2000年至2005年
Helen Dolk1, Maria Loane, Ester Garne
1Professor of Epidemiology and Health Services Research, University of Ulster, Co Antrim, Northern Ireland, UK. h.dolk@ulster.ac.uk
Circulation
|February 16, 2011
概括
在欧洲,先天性心脏缺陷 (CHD) 影响每1000例出生中有8.0例,存在显著的差异. 早期诊断和预防至关重要,以减少估计每年39,000例与冠状动脉疾病相关的死亡和终止.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 遗传学 是一个遗传学.
背景情况:
- 先天性心脏缺陷 (CHD) 是一个重要的全球健康问题.
- 了解CHD的患病率和结果对于公共卫生倡议至关重要.
研究的目的:
- 确定欧洲先天性心脏缺陷 (CHD) 的患病率.
- 评估与心脏病相关的胎儿和产周死亡率.
- 分析欧洲各国心脏病发病率和结果的变化.
主要方法:
- 从16个欧洲国家的29个基于人口的先天性异常登记处收集了数据.
- 这项研究分析了2000年至2005年间330万名出生者的数据.
- 心血管疾病病例包括活产,胎儿死亡 (妊娠20周以上),以及由于胎儿异常 (TOPFA) 导致的妊娠终止.
主要成果:
- 心血管疾病的平均总患病率为每1000例出生8.0例,活产患病率为每1000例出生7.2例.
- 严重的非染色体性冠状动脉疾病发生在每1000例出生中有2.0例,其中40%是产前诊断的,14%导致TOPFA.
- 与唐氏综合征相关的心脏病发生在每1000个活产婴儿中0.5例,在各国之间有超过4倍的差异.
结论:
- 据估计,每年在欧盟约有36000名儿童出生时患有心血管疾病,另外还有3000名儿童死亡 (胎儿,终止或新生儿).
- 投资于初级预防和病原遗传研究对于减轻心血管疾病的负担至关重要.
- 改善从产前诊断到成年期的心脏服务对于更好的结果至关重要.
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