血清 bilirubin 和呼吸系统疾病和死亡的风险
Laura J Horsfall1, Greta Rait, Kate Walters
1Research Department of Primary Care and Population Health, University College London, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, England. laura.horsfall@ucl.ac.uk
JAMA
|February 18, 2011
概括
在健康成年人中,血清胆红素水平较高与呼吸系统疾病风险降低有关,包括慢性阻塞性肺病 (COPD) 和肺癌,以及较低的全因死亡率.
科学领域:
- 肺部医学 肺部医学
- 生物化学 生物化学
- 流行病学 流行病学
背景情况:
- 血清总胆红素水平受到遗传和环境因素的影响.
- 这些因素可能会影响一个人对呼吸系统疾病的易感性.
研究的目的:
- 调查血清胆红素水平与发展呼吸系统疾病的风险之间的关联.
- 检查 bilirubin 水平与全因死亡率之间的关系.
主要方法:
- 一项涉及504,206名成年人的大型队列研究使用英国初级保健数据进行.
- 在没有肝胆道或血液溶解疾病的个体中分析了血清胆红素水平.
- 慢性阻塞性肺病 (COPD),肺癌和全因死亡率的发病率在20年内被跟踪.
主要成果:
- 较高的胆红素水平与男性和女性肺癌,COPD和全因死亡率降低有关.
- 胆红素0.1mg/dL增加与肺癌发病率降低8-11%和男性COPD发病率降低6%有关.
- 经过调整后的分析证实了这些反向关系,表明高 bilirubin 水平具有保护作用.
结论:
- 在正常范围内,较高的血清胆红素水平与呼吸系统疾病风险降低相关.
- 升高的胆红素与一般成年人群中较低的全因死亡率有关.
- 这些发现表明胆红素对呼吸系统疾病和死亡的潜在保护作用.
相关概念视频
Factors Affecting Respiration
8.9K
Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
8.9K
Respiratory Assessment: Purpose and Indications
2.1K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
2.1K
Acute Respiratory Failure-II
1.8K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.8K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
274
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
274
Serum Studies: Renal Function Tests
698
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
698
Jaundice
44
Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
44


