内源性昼夜节律在血管脉应对头向上倾斜的反应
Kun Hu1, Frank A J L Scheer, Michael Laker
1Division of Sleep Medicine, Harvard Medical School, 221 Longwood Ave, 044 BLI, Boston, MA 02115, USA.
昏或昏更有可能发生在生物夜晚,这是由于昼夜系统对心血管应对姿势压力的反应的影响. 这增加了夜班工作者和睡眠障碍患者的风险.
科学领域:
- 心脏病学 心脏病学
- 时间生物学 时间生物学
- 自主神经科学 自主神经科学
背景情况:
- 昏 (昏) 发生率显示出日常模式,可能受到昼夜系统和日常刺激的影响.
- 研究了昼夜系统在调节心血管对姿势压力的反应和昏迷易感性方面的作用.
研究的目的:
- 测试关于昼夜系统调节心血管对姿势压力的反应的假设.
- 为了确定昏迷易感性是否在一天的特定时间变化.
主要方法:
- 12名受试者参加了为期13天的20小时睡眠-清醒周期的方案.
- 倾斜表测试在整个昼夜周期的间隔内进行,以评估心血管反应和昏迷前症状.
主要成果:
- 临睡前的事件表现出显著的昼夜节律 (P=0.028),主要发生在生物夜间 (晚上10:30至早上10:30).
- 循环节律也被观察到在血液动力学和自主性标记物中,包括血压,心率和catecholamines.
结论:
- 昼夜系统显著影响心血管对姿势压力的反应,在生物夜间增加了前眼的易感性.
- 夜班工作者和睡眠障碍患者在生物夜间暴露于姿势压力时,可能面临更高的昏睡风险.
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