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Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
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合成和分子建模提供了对Pseudomonas aeruginosa定数感应难题的洞察力

Joseph S Zakhari1, Isao Kinoyama, Anjali K Struss

  • 1Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|February 26, 2011
PubMed
概括

两个合成的定量感应分子,9和12,在Pseudomonas aeruginosa中表现出类似的活性,尽管结构上有差异. 建模揭示了与LasR受体具有相似的结合特性,解决了细菌通信研究中的先前不一致性.

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